Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.
Identifieur interne : 004695 ( Main/Exploration ); précédent : 004694; suivant : 004696Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.
Auteurs : Linda T. Hiraki [Australie] ; Conghui Qu ; Carolyn M. Hutter ; John A. Baron ; Sonja I. Berndt ; Stéphane Bézieau ; Hermann Brenner ; Bette J. Caan ; Graham Casey ; Jenny Chang-Claude ; Stephen J. Chanock ; David V. Conti ; David Duggan ; Charles S. Fuchs ; Steven Gallinger ; Edward L. Giovannucci ; Tabitha A. Harrison ; Richard B. Hayes ; Aditi Hazra ; Brian Henderson ; Michael Hoffmeister ; John L. Hopper ; Thomas J. Hudson ; Mark A. Jenkins ; Sébastien Küry ; Loic Le Marchand ; Mathieu Lemire ; Jing Ma ; Joann E. Manson ; Hongmei Nan ; Polly A. Newcomb ; Kimmie Ng ; John D. Potter ; Robert E. Schoen ; Fredrick R. Schumacher ; Daniela Seminara ; Martha L. Slattery ; Jean Wactawski-Wende ; Emily White ; Kana Wu ; Brent W. Zanke ; Peter Kraft ; Ulrike Peters ; Andrew T. ChanSource :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1538-7755 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Régime alimentaire, Tumeurs colorectales (génétique), Tumeurs colorectales (sang), Vitamine D (analogues et dérivés), Vitamine D (génétique), Vitamine D (sang).
- MESH :
- analogues et dérivés : Vitamine D.
- génétique : Tumeurs colorectales, Vitamine D.
- sang : Tumeurs colorectales, Vitamine D.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Régime alimentaire.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Vitamin D.
- blood : Colorectal Neoplasms, Vitamin D.
- genetics : Colorectal Neoplasms, Vitamin D.
- Diet, Female, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
Abstract
Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D.
DOI: 10.1158/1055-9965.EPI-13-0209
PubMed: 23983240
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.</title><author><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. Hiraki</name><affiliation wicri:level="1"><nlm:affiliation>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia; Epidemiology Pro</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. 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Slattery</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23983240</idno><idno type="pmid">23983240</idno><idno type="doi">10.1158/1055-9965.EPI-13-0209</idno><idno type="wicri:Area/PubMed/Corpus">003A97</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A97</idno><idno type="wicri:Area/PubMed/Curation">003967</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003967</idno><idno type="wicri:Area/PubMed/Checkpoint">003967</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003967</idno><idno type="wicri:Area/Ncbi/Merge">001437</idno><idno type="wicri:Area/Ncbi/Curation">001437</idno><idno type="wicri:Area/Ncbi/Checkpoint">001437</idno><idno type="wicri:Area/Main/Merge">004806</idno><idno type="wicri:Area/Main/Curation">004695</idno><idno type="wicri:Area/Main/Exploration">004695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.</title><author><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. Hiraki</name><affiliation wicri:level="1"><nlm:affiliation>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia; Epidemiology Pro</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name></author><author><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name></author><author><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="eISSN">1538-7755</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Colorectal Neoplasms (blood)</term><term>Colorectal Neoplasms (genetics)</term><term>Diet</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Vitamin D (analogs & derivatives)</term><term>Vitamin D (blood)</term><term>Vitamin D (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Régime alimentaire</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs colorectales (sang)</term><term>Vitamine D (analogues et dérivés)</term><term>Vitamine D (génétique)</term><term>Vitamine D (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Vitamine D</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Colorectal Neoplasms</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs colorectales</term><term>Vitamine D</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tumeurs colorectales</term><term>Vitamine D</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diet</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Régime alimentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name></noCountry><country name="Australie"><noRegion><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. 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